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Oral presentation
Stephen Jakson
MRC International Tic Research Partnership
We report a multi-centre mega-analysis examining how motor cortex excitability develops across childhood, adolescence, and adulthood in Tourette syndrome (TS). We pooled resting motor threshold (RMT) data collected using TMS from 415 participants (229 with TS; 186 neurotypical controls; CS) collected at 11 international research centres. Individuals ranged in age from 8-48 years, (mean age: CS = 20 ± 7.9 years, TS = 18.7 ± 7.2 years). The groups did not differ in age or in the proportion of males and females in each group. These data allowed us to ask a fundamental question: Does the maturation of motor excitability follow a different developmental trajectory in individuals with TS?
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