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Episode 2: Cannabis-based medicines for the treatment of tics

For our second episode of "Gilles is in the air", Christelle Nilles co-hosts the interview with Dr Natalia Szejko, and together they ask important questions on cannabis-based medicines as a treatment strategy for improving tics.

What is the current evidence for the use of CBM for treatment of tics? How about CBM and comorbid  psychiatric disorders? Can CBM also be helpful? What are the most common side effects?  

When would you consider treatment with CBM in TS? Are there any particular strains that are preferable? Another controversial topic is the use of CBM in children; could this treatment be also considered in children with tics? 

Our guest today, is Professor Kirsten Müller-Vahl from the Hannover Medical School, specialised in neurology and adult psychiatry. Over the past 30 years, she has investigated Tourette syndrome in more than 3,000 patients.

She is the President of the International Alliance for Cannabinoid Medicines (IACM), and past Chair of the ESSTS.

References, studies and papers cited:

  • CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders – Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study. Link
  • Abi-Jaoude E, Bhikram T, Parveen F, Levenbach J, Lafreniere-Roula M, Sandor P. A Double-Blind, Randomized, Controlled Crossover Trial of Cannabis in Adults with Tourette Syndrome. Cannabis Cannabinoid Res. 2023 Oct;8(5):835-845. doi: 10.1089/can.2022.0091. Epub 2022 Aug 30. PMID: 36040329.
  • Mosley PE, Webb L, Suraev A, Hingston L, Turnbull T, Foster K, Ballard E, Gomes L, Mohan A, Sachdev PS, Kevin R, Gordon R, Benson M, McGregor IS. Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome. NEJM Evid. 2023 Sep;2(9):EVIDoa2300012. doi: 10.1056/EVIDoa2300012. Epub 2023 Jun 7. PMID: 38320199.
  • Müller-Vahl KR, Pisarenko A, Ringlstetter R, Cimpianu CL, Fremer C, Weidinger E, Jenz EB, Musil R, Brunnauer A, Großhennig A. The Effect of Nabiximols on Driving Ability in Adults with Chronic Tic Disorders: Results of a Substudy Analysis of the Double-Blind, Randomized, Placebo-Controlled CANNA-TICS Trial. Cannabis Cannabinoid Res. 2024 Jan 23. doi: 10.1089/can.2023.0114. Epub ahead of print. PMID: 38265476.
  • Anis S, Zalomek C, Korczyn AD, Lassman S, Rosenberg A, Gurevich T. Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up. Cannabis Cannabinoid Res. 2023 May 12. doi: 10.1089/can.2022.0281. Epub ahead of print. PMID: 37172308.

Submissions are now closed
All applications will be shared via email with ESSTS members 4 weeks prior to the upcoming board elections. The members will have a chance to review the candidacies and exercise their voting rights online on 8 June 2023.
Wednesday, 7 February 2024, 16:00-19:00 CET
This is an online training course for TS beginners. The course is open to clinicians (physicians, psychologists, psychotherapists, nurses, medical students) and other professionals who are interested in the clinical aspects of TS).
The presentations and the Q&A session will be held in English.
All clinically relevant topics will be covered, including:
Diagnosis and definition of tic disorders
Nature of tics
Course of TS
Differential diagnoses
Pathophysiology including genetics
Registration & online attendance
To confirm your participation, thank you for using the registration form below.
We have introduced a single, moderate registration fee of €25 –applying also to senior professionals– as we wish to encourage the participation of as many junior colleagues as possible.
You will have the option to add a –greatly appreciated!– contribution if you wish, at payment checkout.
You will receive via email approximately 2 weeks-10 days before the event date (7th February 2024) a unique link to access the live session.
Kindly note that this link allows for one single connection per registered attendee.
ESSTS Members 2024 registration
Registration is free of charge for ESSTS Members who will have renewed their membership for the calendar year 2024 at least 24 hours before the online event.
Assessment, including differential diagnoses
Treatment; pharmacological treatment, psychological intervention, deep brain stimulation
Clinical cases; assessment and treatment
Live Q&A session
Registration form
Need a certificate of attendance?
Just say the word! Send us a quick message here.








Meet our country hosts and co-organisers for 2024, Professors Cristiano Termine and Andrea Cavanna, from the University of Insubria and University of Birmingham respectively.
Discover below the spectacular destination where we shall meet again next summer!
Cristiano Termine
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Invited speakers

James Leckman

James Leckman

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Davide Martino

Davide Martino

more details / CV
La TS-school è un evento satellite rispetto alla 16ª Conferenza Internazionale su Disturbi da tic e Sindrome di Tourette.
Questa è la terza edizione della TS-school, un corso di formazione per coloro che vogliono apprendere maggiori informazioni in merito alla Sindrome di Tourette. Il corso è aperto a diverse figure professionali (medici, psicologi, infermieri, specializzandi, studenti di medicina) e altri professionisti interessati agli aspetti clinici della Sindrome di Tourette.
  • Le relazioni si terranno in lingua inglese con traduzione simultanea in italiano
  • Accreditamento ECM per medici, psicologi, infermieri
E’ possibile iscriversi a questo evento separatamente rispetto alla Conferenza.
Martedì 11 giugno 2024, 13:00-18:00 | Palace Grand Hotel Varese
Responsabile scientifico: Prof. Cristiano Termine (Italia)
Cristiano Termine
Verranno trattati diversi argomenti clinicamente rilevanti tra cui:
definizione del disturbo da tic
eziopatogenesi dei tic
decorso della Sindrome di Tourette
diagnosi differenziale
valutazione diagnostica
fisiopatologia (inclusa la genetica)
File PDF
Conferenziere/consiglio dell'ESSTS
Valutazione diagnostica, compresa la diagnosi differenziale
Natalia Szejko (Canada)
Christelle Nilles (France)
Pausa caffè
Trattamento farmacologico, interventi psicologici e stimolazione cerebrale profonda
Kirsten Müller-Vahl (Germany)
Come rispondere alle domande più frequenti di pazienti e familiari in merito all’eziologia e alla fisiopatologia dei tic
Tammy Hedderly (UK)
Casi clinici: dalla valutazione diagnostica al trattamento
Nanette Mol Debes (Denmark)
Mercoledì 12 giugno 2024, ore 14:00-17:00
Aula Magna “Granero-Porati” - via Dunant, 3 Varese
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Introduzione e saluti istituzionali
Prima sessione: Moderatore L. Macchi (Ufficio Inclusione - Ambito Territoriale di Varese)
Seconda sessione: Moderatore S. Bralia (Ufficio Inclusione - Ambito Territoriale di Varese)
Tic, disturbo ossessivo compulsive, autismo e disturbi del movimento funzionali.
Tic e Tourette in classe, cosa fare?
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